在精神分裂症中改变非快速眼动睡眠的频谱
Nataliia Kozhemiako1, Chenguang Jiang2, Yifan Sun2
1Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Boston, USA.
bioRxiv : the preprint server for biology
|January 18, 2024
概括
精神分裂症 (SCZ) 患者在非快速眼动 (NREM) 睡眠神经生理学中表现出显著的变化,超出了群体差异. 这种异质性,部分与药物和年龄有关,为个性化SCZ治疗提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
背景情况:
- 精神分裂症 (SCZ) 与非快速眼动 (NREM) 睡眠期间改变的脑电图 (EEG) 度量相关,包括和缓慢的振荡.
- 之前的研究集中在群体层面的差异上,使得NREM睡眠缺陷和其临床相关的患者之间的差异性在很大程度上未被探索.
研究的目的:
- 复制SCZ患者和对照者之间之前报告的小组级NREM睡眠差异.
- 在更大的SCZ队列中,描述NREM神经生理学中患者对患者变化的程度和性质.
主要方法:
- 利用了来自103名SCZ患者和68名对照者的高密度睡眠EEG数据.
- 分析了NREM睡眠指标,包括螺旋特征和缓慢的振荡,以评估群体差异和个人间的变化.
- 研究了NREM变异性与临床因素,认知特征,年龄和药物治疗方案之间的关联.
主要成果:
- 在SCZ患者和对照人群之间NREM睡眠指标的组级差异被复制,诊断准确度高 (AUC=0.93).
- 与对照组相比,SCZ患者在26%的睡眠指标中表现出显著增加的个体间变异性.
- 虽然临床和认知因素显示了一些关联,但它们不能完全解释NREM异质性的增加;药物和与年龄相关的变化是更重要的贡献者.
结论:
- 睡眠EEG揭示了SCZ中强大的,可复制的NREM睡眠变化,突出显示了群体平均值和群体内部变异.
- 在SCZ中增加的NREM异质性并不能完全通过标准的临床/认知评估来解释,这表明睡眠EEG为个性化医学提供了新的信息.
- 在SCZ中对NREM睡眠频谱的客观,可扩展的测量可以提供有关病因多样性,治疗反应和预后的见解.
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