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Updated: Jul 5, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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小与大图书馆对接用于传感受体的正调节器

Fangyu Liu1, Cheng-Guo Wu2, Chia-Ling Tu3

  • 1Dept. of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco CA 94143, USA.

bioRxiv : the preprint server for biology
|January 18, 2024
PubMed
概括

研究人员通过对接大型分子图书馆,为感应受体 (CaSR) 发现了强大的新型正调节器 (PAM). 这些新型的CaSR PAM有效地降低了副甲状腺激素 (PTH),而不会导致低血症,提供了一种有前途的治疗方法.

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