哺乳动物和鸟类的TRPM8依赖性震动
bioRxiv : the preprint server for biology
|January 18, 2024
概括
湿狗震动 (WDS) 行为对于温度调节至关重要,在哺乳动物和鸟类中都由TRPM8触发. 这一发现表明TRPM8是感知湿度的关键,并且在毛皮和羽毛的物种中演变趋同.
科学领域:
- 动物行为 动物行为
- 感官生物学 感官生物学
- 进化生物学是进化的生物学.
背景情况:
- 热血动物的温度调节需要有效地从毛皮和羽毛中去除水分.
- "湿狗震动" (WDS) 行为在哺乳动物中得到了很好的记录,但在鸟类中研究较少.
- TRPM8被确定为哺乳动物的关键冷感应器,但其在物种间湿气诱导的震动中的作用尚不清楚.
研究的目的:
- 调查TRPM8在不同物种湿度诱导的震动行为中的作用.
- 为了确定TRPM8是否在哺乳动物和鸟类中调解"湿狗震动".
- 探索TRPM8在排水行为中的进化影响.
主要方法:
- 给动物和鸟类使用新型TRPM8激动剂.
- 观察和分析由激动剂和喷水诱导的震动行为.
- 使用TRPM8缺乏的小鼠进行实验验证,以评估WDS的依赖性.
主要成果:
- 一个新的TRPM8激动剂成功诱导了动物和鸟类中的WDS.
- 诱导的震动行为模仿了WDS对水暴露的自然反应.
- 证实TRPM8对于喷水小鼠的WDS发作至关重要.
- 证据表明TRPM8在所有测试物种中对WDS的依赖.
结论:
- 哺乳动物和鸟类的湿气诱导震动行为 (WDS) 取决于TRPM8.
- 在毛和羽毛动物中,TRPM8充当湿度传感器.
- 融合进化可能有利于类似的WDS机制,涉及TRPM8,用于各种物种的水驱逐.
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