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大脑器官中的原序列模型内在的大脑状态作者
Tjitse van der Molen1,2, Alex Spaeth3,4, Mattia Chini5
1Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
bioRxiv : the preprint server for biology
|January 18, 2024
概括
结构化的神经元发射序列在大脑发育的早期出现,存在于人类和小鼠的大脑器官. 这些模式是天生的,不依赖于经验,这表明预先配置的神经架构.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 神经元发射序列是神经编码和信息处理的基础.
- 神经发育期间出现序列的发育时间在很大程度上是未知的.
研究的目的:
- 在早期神经发育期间调查结构化神经元发射序列的出现.
- 要确定这些序列是经验依赖的还是天生的.
主要方法:
- 分析人类和小鼠大脑器官中的自发神经元活动.
- 来自ex vivo新生儿小鼠体感皮质大脑切片的电生理学记录.
- 与初级分离皮质培养物的比较.
主要成果:
- 在人类和小鼠大脑器官和新生儿小鼠大脑切片中确定了结构化的发射序列.
- 观察到一定的时间刚性和灵活的发射模式的平衡作为新兴现象.
- 在初级分离皮层培养物中,这些模式不存在.
结论:
- 时间神经元序列似乎是天生的,受到早期神经发生和预先配置的架构的约束.
- 大脑有机体为研究早期大脑发育和电路组装提供了有价值的模型.
- 进一步的研究可以探索外部输入如何在发育过程中改进神经元电路.
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