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Updated: Jul 5, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Published on: May 2, 2025

使用相关的元分析发现功能和可溶性受体之间的基因组和转录基因组变性,用于先进的糖化最终产品:长寿家庭研究 (LLFS)

Mary F Feitosa, Shiow J Lin, Sandeep Acharya

medRxiv : the preprint server for health sciences

|January 18, 2024

概括

遗传因素影响功能和AGE (sRAGE) 水平的可溶性受体,影响慢性病 (CKD) 和衰老. 共享的遗传元素突出显示了和衰老途径中的作用.

科学领域:

遗传学是一个遗传学.
腎臟病學 (nephrology) 是一種醫學.
老年学是指老年学的学科.

背景情况:

患有慢性病 (CKD) 的患者表现出增加的氧化应激,炎症和先进的糖化最终产品 (AGEs).
高可溶性AGE受体 (sRAGE) 和低估计的球膜过率 (eGFR) 与CKD和衰老有关.
研究eGFR和sRAGE之间的共同遗传因素对于了解脏衰老和疾病至关重要.

结论:

Pleitotropic loci 和 eGFR 和 sRAGE 的基因表达表明它们具有共同的遗传效应.
鉴定到的遗传元素在功能和病途径上得到了丰富.
研究结果强调了共享基因在脏和衰老相关信号通路中的作用.

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相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...