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抑制Wnt可以减轻质母细胞瘤中对免疫检查点阻塞的抵抗力

Rakesh Jain1, Shanmugarajan Krishnan1, Somin Lee1

  • 1MGH.

Research square
|January 18, 2024
PubMed
概括

在质母细胞瘤 (GBM) 中,WNT7b信号导致对免疫检查点抑制剂 (αPD1) 的耐药性. 将WNT抑制剂与αPD1结合在小鼠中改善了生存率,但一些瘤仍然具有抗性,这表明了对GBM的新治疗策略.

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