在精神分裂症中,口腔微生物组与大脑静止状态连接性之间的关联
bioRxiv : the preprint server for biology
|January 18, 2024
概括
精神分裂症 (SZ) 与口腔微生物组合和大脑功能连接的改变有关. 这项研究揭示了特定微生物物种与大脑网络变化之间的显著相关性,这表明在SZ中潜在的微生物组-大脑轴作用.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 微生物组-大脑轴越来越多地被认为对大脑功能和精神疾病的作用.
- 环境因素,包括肠道微生物组,与精神分裂症 (SZ) 有关.
- 这项研究调查了口腔微生物组失调和SZ中大脑电路功能障碍之间的不足探索的联系.
结论:
- 口腔微生物组失调与精神分裂症中大脑功能连接的改变有关.
- 潜在的调解途径包括免疫和神经递质信号传递,以及下丘脑-垂体-上腺轴.
- 这些发现支持进一步研究口腔微生物组在SZ病理生理学和大脑活动中的作用.
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