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Updated: Jul 5, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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KMT2Acoproteins诱导了对向治疗的表观遗传抵抗

Derek H Janssens, Melodie Duran, Dominik J Otto

    bioRxiv : the preprint server for biology
    |January 18, 2024
    PubMed
    概括

    KMT2Acoproteins通过破坏基因表达来驱动白血病,其水平决定了ALL或AML程序. 治疗可以诱导血统切换,通过ENL标记的表观遗传变化导致耐药性.

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