ANKRD2表达与TNFRSF19表达相结合,用于评估口腔状细胞癌患者的预后
Shucong Yao1, Hongwei Xiao1, Changji Wei1
1Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Heliyon
|January 18, 2024
概括
这项研究使用ANKRD2和TNFRSF19开发了一种风险模型,用于预测口腔状细胞癌 (OSCC) 患者的思丁敏感性,帮助治疗决策,并可能克服耐药性.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 西斯是治疗各种癌症的重要化疗药物.
- 许多口腔状细胞癌 (OSCC) 患者在接受西斯普拉丁治疗时表现不佳.
- 在OSCC中预测西斯丁敏感性的生物标志物对于个性化医学是必要的.
研究的目的:
- 开发一种风险模型,用于预测OSCC患者对西斯普拉丁的敏感性.
- 为了在OSCC中确定西斯普拉丁反应的潜在生物标志物.
- 为OSCC治疗中的临床实践提供参考.
主要方法:
- 在OSCC细胞系和TCGA数据中对差异表达基因的查.
- 开发一个包含ANKRD2和TNFRSF19.19的风险模型.
- 使用RT-PCR,病理样本和临床数据验证风险模型.
主要成果:
- 鉴定出ANKRD2和TNFRSF19在西斯治疗的OSCC细胞和耐化细胞系中表达差异.
- ANKRD2和TNFRSF19的表达水平显著影响了OSCC患者的预后.
- 开发的风险模型,结合ANKRD2和TNFRSF19,准确地预测了临床OSCC样本中的西斯普拉丁敏感性.
结论:
- 在OSCC中,ANKRD2和TNFRSF19的表达与西斯普拉丁敏感性和预后相关.
- 高ANKRD2和低TNFRSF19表达表明OSCC患者的生存结果较差.
- 在OSCC中,ANKRD2和TNFRSF19代表了改善思丁疗效的潜在治疗点.
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