草药组合"HAGE-101912"改善了老鼠的胃食道逆流病
Mohammed M Azeemuddin1, Madan M Narendra1, Onkaramurthy Mallappa1
1Research and Development, Himalaya Wellness Company, Makali, Bengaluru, Karnataka, India.
Journal of pharmacy & bioallied sciences
|January 18, 2024
概括
这项研究表明,HAGE-101912,一种草药组合,通过减少酸并保护食道,有效治疗胃食道逆流症 (GERD). 它为GERD管理提供了一个有前途的替代疗法.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 草药是一种草药.
背景情况:
- 胃食道逆流性疾病 (GERD) 由于现代生活方式,越来越普遍.
- 目前的治疗方法,如质子抑制剂 (PPI) 有局限性,需要替代疗法.
研究的目的:
- 为了评估HAGE-101912的疗效,一种草药组合,在GERD的实验模型中.
主要方法:
- 通过H+/K+ATPase抑制和下食道 (LES) 收缩评估抗酸活性.
- 使用大鼠GERD模型 (骨髓和骨髓绑定) 来评估HAGE-101912 (250毫克/公斤).
- 测量了胃的pH值,体积,酸度,食道指数和组织病理学;使用红法评估了生殖活性.
主要成果:
- HAGE-101912表现出显著的酸中和能力和H+/K+ATPase抑制 (P < 0.001,P < 0.01).
- 它增加了 LES 收缩,胃 pH 和受保护的食道上皮,同时降低了胃酸量,总酸度和指数 (P < 0.01).
- 促基因活性导致胃排空和过境的增加 (P < 0.05).
结论:
- 在GERD模型中,HAGE-101912表现出有益的效果.
- 它通过抑制H+/K+ATPase,增加胃pH,恢复LES功能,并保护食道上皮作用.
- 这种草药组合还可以增强胃排空和过境,这表明GERD具有多方面的治疗潜力.
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