在接受非典型抗精神病药物治疗的超重精神分裂症患者中改变的线粒体淋巴细胞及其与认知功能的关联
Yaoyao Zhang1, Wei Tang1, Bei Tang2
1Department of Psychiatry, The Affiliated Kangning Hospital of Wenzhou Medical University Zhejiang Provincial Clinical Research Center for Mental Disorder, Wenzhou, Zhejiang, China.
Frontiers in immunology
|January 18, 2024
概括
接受非典型抗精神病药物的精神分裂症患者显示线粒体T淋巴细胞增加,与体重增加和认知问题有关. 超重患者的数量较高,与BMI相关,影响语言功能.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 精神分裂症和肥胖症与免疫和线粒体功能障碍有共同的联系.
- 在精神分裂症治疗中使用的非典型抗精神病药物与体重增加有关.
- 线粒体功能和免疫反应越来越被认为是精神疾病的关键因素.
研究的目的:
- 在接受非典型抗精神病药物的精神分裂症患者中研究C反应蛋白 (CRP) 水平和线粒体淋巴细胞.
- 在这个患者群体中探索线粒体淋巴细胞,体重增加和认知功能之间的关系.
主要方法:
- 在97名精神分裂症患者和100名对照患者中,通过光染色和流动细胞计量评估了线粒体淋巴细胞计数 (CD3+T,CD3+CD4+T,CD3+CD8+T细胞).
- 使用高灵敏度ELISA测量血清CRP.
- 使用PANSS和RBANS评估临床症状和认知功能.
主要成果:
- 精神分裂症患者的线粒体T淋巴细胞数量高于对照组 (p < 0.05).
- 与体重正常的患者相比,超重患者的CD3 + T和CD3 + CD4 + T细胞计数显著增加.
- 线粒体淋巴细胞计数和CRP水平与BMI正相关;CD3+CD4+T细胞计数与RBANS语言得分负相关.
结论:
- 改变的线粒体T淋巴细胞与接受非典型抗精神病药物治疗的精神分裂症患者的体重增加有关.
- 线粒体淋巴细胞的改变可能会导致认知障碍,特别是语言功能,在这个人群中.
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