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Updated: Jul 5, 2025

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神经精神疾病的人类干细胞建模:从多基因性到融合

Jubao Duan1,2

  • 1Center for Psychiatric Genetics, NorthShore University Health System Research Institute, Evanston, IL, USA.

Medical review (2021)
|January 18, 2024
PubMed
概括

人类诱导的多能干细胞 (hiPSCs) 提供了一种研究神经精神疾病 (NPD) 的新方法. 这些干细胞模型有助于研究人员了解NPD的遗传联系,并开发有针对性的治疗方法.

关键词:
大脑有机体 - - 大脑有机体基因组学就是基因组学.诱导的神经元诱导的神经元诱导的多能干细胞干细胞.神经精神疾病是一种神经精神疾病.

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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