与不同类型的尿路转移相关的尿路微生物群特征:一项比较研究
Yuchao Liu1,2,3, Jingcheng Zhang2,3, Haotian Chen2,3
1Department of Urology, Chongming Branch of Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Frontiers in cellular and infection microbiology
|January 18, 2024
概括
膀癌手术后的尿路转移显著改变了尿液微生物组. орто托普性新膀保留了类似于健康个体的微生物多样性,与其他尿路转移类型不同.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 带有尿路转移 (UD) 的激进囊切除术是肌肉侵入性膀癌的标准.
- 主流的UD类型包括正管神经膀 (Studer),阴道管 (Bricker) 和皮肤尿路静脉管 (CU).
- 在UD之后的尿路微生物学变化尚未得到充分理解.
研究的目的:
- 为了研究和比较不同类型的尿路微生物群特征.
- 确定影响尿道微生物多样性的因素,在UD后.
- 评估微生物群在优化UD管理方面的潜力.
主要方法:
- 从健康的志愿者和接受Studer,Bricker或CU的膀癌患者收集尿液样本.
- 使用16S核糖体RNA基因测序分析了微生物组.
- 在不同群体中比较微生物多样性,分布和功能.
主要成果:
- 健康对照人群表现出尿液中微生物丰富度和多样性的最高水平.
- 研究UD患者,特别是那些没有水或余尿的患者,比布里克和CU组显示出明显更高的α-多样性.
- 斯图德UD是促进尿液微生物多样性的唯一独立因素,其微生物群结构与健康个体最相似.
结论:
- 这项研究提供了UD患者的第一个全面的尿道微生物景观.
- орто托普新膀 (Studer) 显示出比其他UD类型的微生物优势.
- 尿路微生物群有可能成为优化UD管理的工具.
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