在患有非小细胞肺癌的老年患者中,血液生物标志物的预测值
Lianghua Guo1, Bin Song1, Jianhong Xiao1
1Department of Respiratory Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fuan, 355000, China.
Biomarkers in medicine
|January 18, 2024
概括
这项研究表明,血液中的GRHL1可能有助于在老年人中检测非小细胞肺癌 (NSCLC). 在老年人群中,循环的GRHL1显示为早期NSCLC查的生物标志物具有前途.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 老年医学 老年医学
背景情况:
- 非小细胞肺癌 (NSCLC) 仍然是癌症相关死亡的主要原因.
- 早期发现NSCLC对于改善患者的治疗结果至关重要.
- 在老年人群中确定可靠的NSCLC查生物标志物是一个未满足的临床需求.
研究的目的:
- 调查循环GRHL1作为NSCLC检测生物标志物的潜力.
- 评估血液GRHL1在老年人中识别NSCLC的诊断价值.
主要方法:
- 用351名被诊断患有NSCLC的老年患者的数据开发了诊断模型.
- 进行了统计分析,以评估GRHL1对NSCLC的预测值.
主要成果:
- 在调整了混杂因素后,GRHL1与NSCLC发病率的增加显著相关 (几率比:3.25;p < 0.001).
- 血清GRHL1对NSCLC检测具有良好的预测价值,曲线下的面积为0.725 (p < 0.001).
结论:
- 循环中的GRHL1显示出作为NSCLC生物标志物的显著潜力.
- 这项研究提供了GRHL1在老年人群中早期检测NSCLC的有用性的第一个证据.
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