在COVID-19感染后,阻塞性睡眠呼吸暂停综合征的患病率
Wen-Chun Lin1,2, Meng-Che Wu3,4,5, Yu-Hsun Wang1,6
1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Journal of medical virology
|January 18, 2024
概括
在幸存者中,COVID-19感染增加了发展阻塞性睡眠呼吸暂停 (OSA) 的风险. 这项研究发现,与没有COVID-19的人相比,患有COVID-19的人的新OSA诊断发生率显著更高.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 肺部病理学 肺部病理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种已知的严重COVID-19的风险因素.
- 有限的研究存在于COVID-19幸存者的OSA患病率.
- 了解COVID-19后的呼吸系统状况至关重要.
研究的目的:
- 调查COVID-19感染与随后阻塞性睡眠呼吸暂停风险之间的关联.
- 为了量化SARS-CoV-2感染后发展OSA的风险.
主要方法:
- 使用美国协作网络在TrinetX数据中的回顾性队列研究 (2020年1月 - 2022年6月).
- 包括对SARS-CoV-2 (PCR测试) 进行测试的参与者.
- 在12个月内,使用Cox比例危险模型,在COVID-19阳性和阴性组之间比较新诊断的OSA风险.
主要成果:
- COVID-19幸存者在感染后3个月 (HR: 1.51) 和1年 (HR: 1.57) 显著增加了OSA的风险.
- 卡普兰-梅尔曲线证实了组之间OSA概率的显著差异 (Log-Rank测试,p < 0.001).
- 在所有分析的年龄,性别和种族小组中观察到增加的OSA风险.
结论:
- COVID-19感染与新的阻塞性睡眠呼吸暂停诊断的发生率大幅增加有关.
- 医生应考虑在有COVID-19病史的患者中对OSA进行查.
- 早期评估COVID-19后的OSA可能有助于预防长期的心血管和神经血管并发症.
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