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Updated: Jul 5, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
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Published on: March 5, 2022

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通过PIAS1对m6A阅读器YTHDF2的SUMOylation促进病毒RNA衰变,以限制EBV复制

Febri Gunawan Sugiokto1,2, Farjana Saiada1, Kun Zhang1,3

  • 1Department of Oral and Craniofacial Molecular Biology, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia, USA.

mBio
|January 18, 2024
PubMed
概括

通过促进YTHDF2的SUMOylation,PIAS1增强了YTHDF2的抗埃普斯坦-巴尔病毒 (EBV) 活性. 这种调节控制了病毒mRNA的稳定性,并限制了EBV的复制,影响了m6ARNA修饰途径.

关键词:
爱斯坦-巴尔病毒病毒.在 PIAS1 的基础上.在RNA衰变过程中,RNA衰变.基因组RNA的修饰是RNA的修饰.这就是SUMOylation的作用.这就是YTHDF2的原因.性的复制 性的复制m6A 一个很好的.限制因子的限制因子

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