间歇性肺部疾病的住院率:对肺纤维化基金会注册表的分析
Christopher S King1, Rosalinda V Ignacio2, Vikramjit Khangoora1
1Advanced Lung Disease and Transplant Program, Inova Fairfax Medical Center, Falls Church, Virginia.
American journal of respiratory and critical care medicine
|January 18, 2024
概括
在间歇性肺病 (ILD) 类型中,住院率相似. 与呼吸系统相关的住院治疗,但不是全因,显著影响存活率,与IPF相比,在结缔组织疾病相关的ILD和非IPF IIP中观察到较低的住院后死亡率.
科学领域:
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 有限的数据存在于医院住院模式和结果的间歇性肺部疾病 (ILDs) 超出异常性肺纤维化 (IPF).
- 了解住院频率及其对各种ILD亚型的存活率的影响,对于患者管理至关重要.
研究的目的:
- 调查各种ILD分类中的住院患者住院的频率.
- 确定住院和患者结果之间的关联,包括住院后的生存率.
主要方法:
- 来自肺纤维化基金会患者登记册的数据分析.
- 在不同类型的ILD之间比较住院住院率和住院后生存率.
- 在生存分析中对伴随性疾病和疾病严重程度进行统计调整.
主要成果:
- 在ILD亚型中,住院率相似:IPF (40.6%),结缔组织疾病相关的ILD (CTD-ILD,42.8%),非IPF异常性间歇性肺炎 (IIP,44.9%),慢性过敏性肺炎 (CHP,46.5%) 和其他ILD (53.3%).
- 所有原因的住院治疗并没有显著降低无移植生存率 (AHR 1.20,P=0.0759).
- 与呼吸系统相关的住院病例与减少无移植生存率有关 (AHR 1.53,P=0.0001).
- 与IPF相比,CTD-ILD (HR 0.43,P=0.0031) 和非IPF IIP (HR 0.3,P=0.005) 的住院后死亡风险较低.
- 热血病和其他ILD显示出与IPF可比的住院后死亡风险.
结论:
- 在各种间歇性肺病亚型中,住院率相似.
- 与呼吸系统相关的住院治疗是ILD患者生存率较差的重要预测因素.
- 与IPF患者相比,CTD-ILD和非IPF IIP患者在住院后的生存率更好.
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