疹感染的危险因素:系统审查和元分析揭示了共同的趋势和异质性模式
Maren Steinmann1, David Lampe2, John Grosser2
1Department of Health Economics and Health Care Management, School of Public Health, Bielefeld University, Bielefeld, Germany. maren.steinmann@uni-bielefeld.de.
Infection
|January 18, 2024
概括
许多慢性疾病增加了疹子 (HZ) 的风险. 这项研究确定了21种风险因素,其中移植是最大的风险,强调了针对免疫受损个体制定有针对性的预防策略的必要性.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 带状疹 (HZ) 对健康构成重大负担.
- 慢性潜在疾病被认为是HZ发病的诱导风险因素.
- 综合综合证据对于理解高温带风险因素至关重要.
研究的目的:
- 系统地识别和综合有关慢性疾病的证据,这些疾病作为疹 (HZ) 的风险因素.
- 量化各种慢性疾病与患上HZ的风险之间的联系.
主要方法:
- 在主要数据库 (MEDLINE,EMBASE,Web of Science) 中对2003年至2023年间发表的研究进行了系统的文献搜索.
- 采用随机效应模型来计算已识别的风险因素的聚合几率比率 (OR).
- 进行了敏感性分析,包括异常值移除和GOSH图片以及多重元回归来评估发现的异质性和稳定性.
主要成果:
- 八十项研究,包括6,392条记录,被纳入了元分析.
- 确定了21种不同的情况作为HZ的重大风险因素.
- 移植表现出最高的相关风险 (OR = 4.51),其他的因素从OR = 1.17到2.87不等,所有这些都表明HZ风险增加.
结论:
- 所有21种已识别的慢性疾病都与疹感染的风险增加有关.
- 这些发现强调了识别和管理这些并发症的重要性,以潜在地减轻HZ发病率.
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