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同时综合增强 (SIB) 与门癌患者的顺序增强:单中心体验

Divya Khosla¹, Rakesh Kapoor¹, Treshita Dey²

¹Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Journal of gastrointestinal cancer

|January 18, 2024

概括

对癌化学辐射的同时整合增强 (SIB) 方法显示了与顺序增强方法相似的生存结果,但急性毒性显著降低. 这种SIB技术为癌治疗提供了耐受性良好的替代方案.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

同时化学辐射是门癌症的标准治疗方法.
辐射传递可以利用顺序增强或同时集成增强 (SIB) 技术.
将这些方法进行比较对于优化患者治疗结果和毒性概况至关重要.

研究的目的:

在接受化学辐射治疗的门癌症患者中,比较顺序增强与SIB的治疗结果和毒性.
评估整体存活率 (OS),无结肠杆菌存活率 (CFS) 和无复发存活率 (RFS).
评估与每个辐射输送方法相关的急性毒性概况.

主要方法:

道状细胞癌患者接受激进化学辐射治疗 (2019-2022) 的回顾性分析.
连续提升包括25个分数中的45 Gy,然后是9 Gy的提升;SIB遵循RTOG 0529协议.
两组都接受了体积调制弧线疗法 (VMAT);结果和毒性进行了比较.

主要成果:

与顺序手臂相比,SIB手臂的整体急性毒性发生率明显较低 (p=0.006).
两年的CFS是80% (顺序) 与87.5% (SIB) 相比;两年的OS是83.3% (顺序) 与58.6% (SIB).
疾病复发发生在77.8% (序列性) 与50% (SIB) 的患者中;盆腔淋巴结的参与影响了OS, inguinal节点影响了RFS.

结论:

与SIB-VMAT同时进行化学辐射对于癌是耐受良好的.
SIB方法导致治疗中断较少,结果与顺序方法相比较.
需要进一步的前性研究来验证这些发现.

关键词:

门癌症是一种门癌症.提升提升提升在 SIB SIB 中.顺序式的顺序式的幸存的生存方式这就是为什么VMAT VMAT.

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