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Updated: Aug 11, 2026

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

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与光生物调节相关的IL-1β对抗受体加速糖尿病伤口组织修复

Rubya Pereira Zaccaron1, Laura de Roch Casagrande1, Ligia Milanez Venturini1

  • 1Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health, Universidade Do Extremo Sul Catarinense, Santa Catarina State, Av. Universitária, 1105 Universitário-Block S, Room 17, Criciúma, 88806-000, Brazil.

Inflammation
|January 18, 2024
PubMed
概括

这项研究将光生物调制 (PBM) 与IL-1β抑制剂结合起来,以加速糖尿病伤口愈合. 在糖尿病小鼠中,联合疗法减少了炎症,增加了愈合因素,并显著减少了伤口大小.

关键词:
糖尿病的伤口这是一种炎症炎症炎症炎症.氧化压力.氧化压力.这是一种类.通过光生物调节.

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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...