用于确定维生素D代谢物的标准参考材料 (SRM) 的演变和影响
Stephen A Wise1, Adam J Kuszak2, Johanna E Camara3
1Office of Dietary Supplements (ODS), National Institutes of Health (NIH), Bethesda, MD, 20817, USA. stephen.wise@nih.gov.
Analytical and bioanalytical chemistry
|January 18, 2024
概括
美国国家标准与技术研究所为维生素D代谢物测量开发了标准参考材料® (SRM). 这些SRM提高了测定准确性和可比性,确保可靠的维生素D状态评估.
科学领域:
- 临床化学 临床化学
- 分析化学 分析化学
- 生物化学 生物化学
背景情况:
- 对维生素D测定准确性和可比性的担忧促使开发标准化材料.
- 国家标准与技术研究所 (NIST) 和国家卫生研究院,食补充剂办公室 (NIH ODS) 合作解决这些问题.
研究的目的:
- 审查维生素D代谢物的标准参考材料® (SRMs) 的发展和演变.
- 评估SRM对维生素D测量质量保证和验证的影响.
主要方法:
- 血清矩阵和校准溶液SRM的开发,其中包括外源和内源维生素D代谢物.
- 使用参考测量程序 (RMP) 和多方法方法进行值赋值.
- 追踪SRM的分发 (销售) 和科学文献以进行使用分析.
主要成果:
- 一套五个血清矩阵和三个校准溶液SRM现在可用,经过14年.
- SRM已经从外源的内容演变为主要的内源内容,价值赋值转向RMP.
- SRM被广泛用于方法验证,质量控制和维生素D分析研究.
结论:
- 美国国家实验研究院的SRM显著提高了维生素D代谢物测量的准确性和可比性.
- SRM和认证方法的演变提高了它们对质量保证的有用性.
- 在科学界内,SRM在确保可靠的维生素D状态评估方面发挥着至关重要的作用.
关键词:
25 基维生素 D2 的含量25 基维生素 D3 的含量3-epi-25-Hydroxyvitamin D3 的使用方法参考测量程序 (RMP) 是指指标测量程序.总的25-基维生素D.维生素D结合蛋白 (VDBP) 是一种维生素D结合蛋白.更多相关视频
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