失控:压力和焦虑相关疾病中的计算动态控制功能障碍
Jonathon R Howlett1,2, Martin P Paulus3
1VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA, 92161, USA. jhowlett@health.ucsd.edu.
Discover mental health
|January 18, 2024
概括
控制理论通过绘制神经回路,为计算精神病学提供了洞察力. 比例-积分-导数 (PID) 控制模型的人类行为,与与恐惧和大脑结构相关的参数,表明压力影响目标导向控制.
科学领域:
- 计算精神病学是一种计算精神病学.
- 神经科学是一个神经科学.
- 控制理论 控制理论 控制理论
背景情况:
- 控制理论在历史上推动了技术进步,并为生物和神经系统提供了关键的见解.
- 人们对将控制理论原则应用于计算精神病学越来越感兴趣.
研究的目的:
- 审查控制理论在计算精神病学中的应用现状.
- 介绍一个神经控制电路模型,涉及额叶皮质,顶叶皮质和小脑.
- 探索奖励,成本和兴奋在调节这种电路中的作用.
主要方法:
- 对计算精神病学中控制理论现有研究的审查.
- 核心神经反控制电路的识别.
- 应用比例-积分-导数 (PID) 控制作为人类行为模型.
主要成果:
- 已经绘制了一个神经控制电路,涉及额叶皮质,皮质和小脑.
- 这种电路是由奖励/成本信号 (基底腺) 和兴奋状态 (insula,ACC,杏仁体,coeruleus位置) 调节的.
- PID控制参数与自我报告的恐惧和影响相关的大脑区域变化相关.
结论:
- 功能障碍的压力和兴奋系统可能会损害目标导向的控制算法,影响复杂的任务.
- 需要进一步的研究来确定控制缺陷在压力/焦虑障碍中的因果关系.
- 控制理论的洞察力有可能为治疗精神疾病开发出临床上有用的工具.
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