在西班牙,阿布罗西提尼布与其他严重的无皮炎全身治疗方法相比的成本效益分析
Rosa María Romero Jiménez1, Pedro Herranz Pinto2, Minia Campos Domínguez1
1Hospital General Universitario Gregorio Marañón, Madrid, Spain.
PharmacoEconomics - open
|January 18, 2024
概括
阿布罗西替尼 (abrocitinib) 是一种治疗严重的亚托皮性皮炎 (AD) 的经济有效的治疗方法,与dupilumab等其他疗法相比,它提供了更大的益处和更低的成本. 这一分析支持了它在西班牙国家卫生系统中的价值.
科学领域:
- 皮肤病学 皮肤病学
- 药物经济学 药物经济学
- 卫生技术评估 卫生技术评估
背景情况:
- 亚托皮炎 (AD) 是一种慢性炎症性皮肤疾病,需要有效和经济可行的治疗方法.
- 现有的严重阿尔茨海默症疗法需要成本效益评估,以指导医疗保健决策.
- 西班牙国家卫生系统 (NHS) 的观点对于评估治疗价值至关重要.
研究的目的:
- 为了评估abrocitinib (200毫克) 与其他治疗严重的亚托皮性皮肤炎的成本效益.
- 可以进行比较的药物包括dupilumab,tralokinumab,baricitinib和upadacitinib.
- 分析重点是西班牙NHS的观点.
主要方法:
- 使用混合决策树和马尔科夫模型进行分析.
- 关键结果包括成本,质量调整后寿命年 (QALYs) 和响应率 (EASI-75).
- 使用了10年的时间视界和25,000欧元/QALY的支付意愿门.
主要成果:
- 与所有替代品相比,阿布罗西提尼布200毫克显示出主导地位,显示成本更低,益处更高.
- 与abrocitinib相比,观察到显著的QALY收益和成本节省.与比较者相比,观察到abrocitinib的QALY收益和成本节省.
- 在大多数模拟和5年时间范围内,Abrocitinib被发现是占主导地位或具有成本效益.
结论:
- 阿布罗西提尼布代表了严重的亚托邦性皮肤炎的经济有效的治疗选择.
- 这些发现支持abrocitinib与其他Janus激酶 (JAK) 抑制剂和生物疗法相比的价值.
- 本经济评估提供了西班牙NHS的证据.
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