长期风险和预测主要角度关闭嫌疑人的进展
Yixiong Yuan1,2,3, Ruilin Xiong1,2,3, Wei Wang1,2,3,4
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
JAMA ophthalmology
|January 18, 2024
概括
预测从主角闭合嫌疑人 (PACS) 到主角闭合 (PAC) 的进展至关重要. 较高的眼内压力 (IOP) 和较浅的前腔深度预测14年后风险增加.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 前段成像前段成像的使用
背景情况:
- 识别疑似初级角闭眼 (PACS) 眼睛有发展至初级角闭眼 (PAC) 的风险对于管理至关重要.
- 对PACS进展风险和预测的长期纵向研究是有限的.
研究的目的:
- 为了确定从PACS到PAC的14年进展的基线预测因素.
- 开发PACS到PAC进展的预测模型.
主要方法:
- 来自中山角关闭预防试验的377个未经治疗的PACS眼睛的队列研究.
- 基线评估包括光度测量,生物测量和前段光学连贯性断层扫描 (AS-OCT) 在明暗条件下.
- 后勤回归模型被用来预测14年进展风险.
主要成果:
- 25%的眼睛在14年内从PACS发展到PAC.
- 较高的眼内压力 (IOP),较浅的中央和四肢前腔深度 (ACD),较小的脊椎虹膜空间面积 (TISA) 和角度隙面积 (ARA) 与进展风险增加有关.
- 使用IOP和ACD的预测模型表现中等;AS-OCT指标没有显著改善预测.
结论:
- 较高的内压,较浅的ACD和较小的TISA/ARA可能预测PAC眼中的PAC进展.
- 这些因素可以帮助定制PACS患者的管理策略.
- 进一步的研究可能会改进预测模型,以便更好地临床应用.
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