在阴道药物输送中使用3D打印:制药制造业的革命
Sagar Narala1, Ahmed Adel Ali Youssef1,2, Siva Ram Munnangi1
1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, USA.
Expert opinion on drug delivery
|January 18, 2024
概括
三维 (3D) 打印为量身定制的药物输送系统提供了灵活的制造. 本综述探讨了3D打印的阴道应用,强调了临床采用的潜力和挑战.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统是药物输送系统.
- 生物医学工程 生物医学工程
背景情况:
- 首个3D打印平板电脑的批准激发了对各种药物输送系统3D打印的兴趣.
- 3D打印允许制造灵活性,使复杂的剂量形式具有针对个体患者需求的定制释放配置文件.
研究的目的:
- 为制药研究中的3D打印技术提供全面的审查.
- 探索3D打印药物输送系统用于阴道输送的应用.
- 讨论当前的研究,挑战和3D打印在阴道药物输送中的未来前景.
主要方法:
- 对药品中3D打印技术的现有文献的审查.
- 与药物输送有关的阴道解剖学和生理学的分析.
- 对3D打印的阴道器件 (戒指,插件,微型设备) 的研究进行审查.
主要成果:
- 3D打印可以创建定制的阴道药物输送设备,如戒指和插件.
- 这些设备可以根据特定的药物释放概况进行设计,优化治疗结果.
- 这项技术有助于开发可生物降解的微型设备,用于定向的阴道药物输送.
结论:
- 3D打印对于推进定制和控制释放的阴道药物输送系统具有重大前景.
- 克服监管障碍,确保安全性,有效性和生物相容性对于临床转化至关重要.
- 进一步的研究和广泛的测试对于实现3D打印阴道治疗的全部潜力至关重要.
相关概念视频
01:16Drug Delivery: Overview
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
294
01:22Drug Delivery: Miscellaneous Routes
344
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
344
01:18Drug Delivery: Enteral Route
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
456
01:29Drug Delivery: Parenteral Route
536
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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