使用基于深度学习的形态分析检测周围血液中的循环血细胞
Pu Chen1, Lan Zhang1, Xinyi Cao2
1Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Cancer
|January 18, 2024
概括
一个名为Morphogo的AI系统准确地检测到多发性骨髓瘤 (MM) 患者的循环血细胞 (CPC). 这种先进的技术提供了比手动方法更高的灵敏度,以改善诊断和预后.
科学领域:
- 血液学 血液学 血液学
- 人工智能的人工智能
- 数字病理学数字病理学
背景情况:
- 循环血细胞 (CPC) 是多发性骨髓瘤 (MM) 诊断,分期和监测的关键指标.
- 通过手动显微镜检测传统的CPC检测在灵敏度和可重现性方面存在局限性.
- 需要更灵敏,更有效的方法来检测周围血液 (PB) 中的CPC.
研究的目的:
- 开发和评估基于人工智能 (AI) 的自动化系统,用于CPC形态检测.
- 与手动显微镜相比,提高CPC识别的灵敏度和效率.
主要方法:
- 对137个骨髓和72个PB涂抹进行了回顾性审查.
- 在一个由AI驱动的数字病理学平台上的305,019个细胞图像上训练一个AI系统 (Morphogo).
- 评估Morphogo在184个额外的PB涂抹上的疗效,并与手动显微镜进行比较.
主要成果:
- 在CPC分类中,Morphogo实现了99.64%的准确性,89.03%的灵敏性和99.68%的特异性.
- 在0.60的值下,Morphogo显示了96.15%的灵敏度,大约是手动显微镜的两倍.
- 人工智能检测CPC与明显较短的无进展生存时间 (18个月与34个月) 相关联.
结论:
- 莫尔福戈是一个高度敏感的系统,用于自动化CPC检测.
- 人工智能系统显示出初始查,预后预测和MM患者治疗后监测的潜力.
- 自动化CPC检测为MM诊断和风险评估提供了更容易获得和更有效的方法.
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