相关实验视频

Updated: Jul 5, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

使用定量化化学交换和转移MRI绘制结质瘤的pH映射:近等稳定状态,溢出和MT纠正的欧米茄图谱分析

Ying Liu^1,2, Yin Wu³, Yang Ji⁴

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.

Journal of magnetic resonance imaging : JMRI

|January 18, 2024

概括

这项研究表明,使用化学交换和转移 (CEST) 图像的优化欧米茄图谱分析可以准确量化质瘤pH. 这种方法为脑瘤的in-situ pH绘制提供了一种可行的方法.

科学领域:

生物医学成像技术生物医学成像技术
神经瘤学神经瘤学
量化MRI是指数量化的MRI.

背景情况:

现场pH测绘对于了解质瘤进展和指导治疗至关重要.
化学交换和转移 (CEST) 提供非侵入性pH成像,但在质瘤中面临量化挑战.

研究的目的:

通过测量质子交换率,用优化的欧米茄图形分析量化质瘤pH值.
建立一种可靠的方法,用于在质瘤中实地测量pH值.

主要方法:

使用11.7T和7.0T的CEST成像进行前性研究.
采用了欧米茄图形分析,准稳定状态 (QUASS) 分析和多池的洛伦兹拟合.
在肌酸幻体,老鼠质瘤外移植和人类质瘤患者中得到验证.

主要成果:

欧米茄图形分析显示,在质瘤中,MTRrex和 ω12之间存在线性相关性 (R2>0.98).
质瘤pH测量独立于度变化.
鼠类质瘤与正常组织相比呈现较低的交换率 (P=0.025),这种模式反映在人类质瘤中.

结论:

基于QUASS,溢出和MT校正的欧米茄图形分析是量化质瘤pH的可行方法.
这种技术使得可靠的现场pH测绘能够改善质瘤的评估.
这些发现支持先进的MRI技术在脑瘤表征方面的临床实用性.

关键词:

在CEST中,CEST是CEST.汇率汇率是指汇率的汇率.质瘤质瘤是一种欧米茄地图图片欧米茄地图图片它们的pH值为pH.

更多相关视频

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

相关概念视频

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...