协调病毒研究:病毒传染病本体学
John Beverley1,2, Shane Babcock2,3, Gustavo Carvalho4
1Department of Philosophy, University at Buffalo, Buffalo, NY, United States of America.
PloS one
|January 18, 2024
概括
本体学通过标准化数据解释来增强COVID-19研究. 病毒传染病本体学 (VIDO) 和冠状病毒传染病本体学 (CIDO) 提高了数据的一致性,并防止了孤岛.
科学领域:
- 生物医学信息学 生物医学信息学
- 传染病研究 传染病研究
- 本体学 工程学 工程学
背景情况:
- 由于COVID-19大流行,需要对SARS-CoV-2研究进行快速数据分析.
- 一致的数据解释对于避免数据孤岛和确保研究可重复性至关重要.
- 实体学提供结构化的词汇,以标准化科学数据.
研究的目的:
- 描述在COVID-19研究中的本体论的应用.
- 引入病毒传染病本体学 (VIDO) 作为传染病本体学 (IDO) 核心的扩展.
- 展示VIDO和CIDO与SARS-CoV-2数据注释的现有本体学的集成.
主要方法:
- 根据开放的生物和生物医学本体学 (OBO) 造原理开发VIDO.
- 重新使用现有的OBO本体学,包括IDO Core.
- 用VIDO和CIDO的术语对SARS-CoV-2研究数据进行注释.
- 将VIDO连接到CIDO和其他相关的实体学.
主要成果:
- 视频提供了病毒传染病的参考本体学.
- 具有共同的高级词汇的本体学可以无集成.
- 使用VIDO和CIDO证明了SARS-CoV-2研究数据的成功注释.
- 突出了宿主病原体数据分析和EHR注释中的本体学的潜力.
结论:
- 实体学,特别是VIDO和CIDO,对于传染病研究中数据的一致解释至关重要.
- OBO Foundry 原则有助于开发和整合专门的本体学.
- 未来的工作包括将本体学扩展到其他传染病原体和数据分析和医疗保健中的应用.
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