在活跃的长期Covid中,持续的补体调节失调带有血栓炎症的迹象
Carlo Cervia-Hasler1, Sarah C Brüningk2,3, Tobias Hoch1
1Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
概括
长期的Covid涉及免疫系统的失调,特别是补体系统. 这项研究确定了补充和血栓炎性蛋白质作为长期COVID诊断和治疗的关键生物标志物.
科学领域:
- 免疫学
- 蛋白质组学
- 传染性疾病
背景情况:
- 长期Covid是一种复杂的,令人衰弱的疾病,原因不明.
- 了解潜在的生物机制对于开发有效的治疗方法至关重要.
研究的目的:
- 通过多模式蛋白质组学研究长期COVID的分子机制.
- 确定长期COVID诊断和治疗目标的潜在生物标志物.
主要方法:
- 感染后12个月的268名COVID-19患者血清的长度蛋白质组分析.
- 对6500多种蛋白质进行分析,以确定长期Covid和康复个体之间的差异.
- 机器学习用于识别顶级蛋白质生物标志物.
主要成果:
- 长期Covid的特征是补充系统的失调激活,包括终端,替代和经典途径.
- 观察到血液溶解的标志物增加,组织损伤,血小板激活和单细胞-血小板聚合.
- 对疹病毒的抗体标位与经典补体通路激活相关.
结论:
- 补体系统和血栓炎症是长期Covid病变的核心.
- 补充和血栓炎性蛋白质显示为长期Covid的诊断和治疗生物标志物.
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