长期COVID患者的程序运动记忆缺陷
William Hayward1, Ethan R Buch1, Gina Norato1
1From the Human Cortical Physiology and Neurorehabilitation Section (W.H., E.R.B., F.I., D.D., R.F.S.-G., L.G.C.), Clinical Trials Unit (G.N.), Office of the Clinical Director, and Section of Infections of the Nervous System (E.B., B.W., A.N.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.
长期COVID患者 (急性呼吸综合征冠状病毒2感染后的长期症状) 可以与健康人群相比学习新的运动技能. 然而,它们的初始性能较慢,一夜之间记忆巩固减少,这表明潜在的执行功能障碍和程序性记忆缺陷.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 长期COVID,其特点是急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染后的持续症状,影响至少15%的幸存者.
- 常见的长期COVID症状包括像"脑雾"和声明记忆受损等认知缺陷.
- 长期COVID对程序性运动技能学习和记忆的影响在很大程度上是未知的.
研究的目的:
- 调查长期COVID患者获得和巩固新流程运动技能的能力.
- 在长期COVID患者和健康对照者之间比较早期学习,技能获取率和记忆巩固.
主要方法:
- 一个前性的,横截面的,在线的病例控制研究,涉及两天内连续的运动技能打字任务.
- 参与者包括长期COVID患者 (症状>4周) 和年龄/性别匹配的健康对照 (流行病和流行病前队列).
- 关键指标包括打字速度,准确性,早期学习 (初步试验),学习率和一夜之间整合.
主要成果:
- 在长期COVID患者和两组对照组之间,早期运动技能学习是可比的 (p=0.82).
- 长期COVID患者在两天的训练中表现出较慢的初始和最终打字速度.
- 在长期COVID组中观察到夜间记忆巩固的显著减少,学习率下降的趋势.
结论:
- 虽然在长期COVID中保留了对新程序运动技能的初始学习,但表现较慢表明执行功能障碍.
- 减少一夜间整合指向了长期COVID患者程序记忆形成的潜在缺陷.
- 这些发现突出了特定的认知障碍,在SARS-CoV-2感染后可能持续很长时间.
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