对治疗的细胞质量反应与一系列恶性瘤的临床反应相关
Mark M Stevens1, Robert J Kimmerling1, Selim Olcum1
1Travera, Medford, MA.
JCO precision oncology
|January 18, 2024
概括
基于细胞质量的响应测试 (MRT) 可以准确预测癌症患者的药物敏感性,与临床结果具有很高的一致性. 这种ex vivo方法可用于各种癌症类型的广泛临床应用.
科学领域:
- 在瘤学瘤学.
- 精准医学是一门精准的医学.
- 生物技术是生物技术.
背景情况:
- 晚期癌症患者往往具有有限的治疗选择和不良预后.
- 基于基因组学的疗法只对一小部分癌症患者有益.
- 活体药物反应测试为更广泛的患者群体提供了潜在的精准医学方法.
研究的目的:
- 评估活细胞质量反应测试 (MRT) 的临床可行性和准确性,以预测患者的药物敏感性.
- 评估MRT作为瘤学中的精准医学工具的潜在影响.
主要方法:
- 一个统一的工作流被用于活细胞MRT与48小时的周转时间.
- 104名患有固体和血液性恶性瘤的患者提供了各种组织样本 (活检,液体,吸血剂,血液).
- 临床反应与医生选择疗法的体外MRT预测相关.
主要成果:
- 磁力共振反应与临床反应具有很高的一致性 (OR = 14.80,P = .0003).
- 该测试显示了80%的高预测精度 (P = .0026).
- 在固体 (OR = 20.67) 和血液 (OR = 8.20) 恶性瘤中,表现一致.
结论:
- 基于群体的响应测试 (MRT) 显示出与癌症治疗的临床反应具有高度显著的相关性.
- 常规临床使用MRT在技术上是可行的,并且在各种样本和恶性瘤类型中广泛适用.
- 未来的验证研究有必要支持将MRT纳入临床实践.
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