在老年患者中解决癌症厌食症-缓解症:潜在的治疗策略和分子途径
Theocharis Ispoglou1, Deaglan McCullough1, Angela Windle2
1Carnegie School of Sport, Leeds Beckett University, Leeds, UK.
Clinical nutrition (Edinburgh, Scotland)
|January 18, 2024
概括
癌症缓解症 (CC) 综合征会导致肌肉消耗,特别是在老年人中. 本综述探讨了管理CC的策略,重点关注对这个脆弱人群的食欲刺激和营养支持.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 代谢过程中的代谢.
背景情况:
- 癌症缓解症 (CC) 是一种复杂的综合征,其特点是肌肉消耗和食欲下降,特别影响老年癌症患者.
- 目前用于CC的治疗方法,包括食欲兴奋剂和营养支持,具有局限性和潜在的副作用.
研究的目的:
- 审查癌症缓解症的分子机制,专注于厌食症在肌肉消耗中的作用.
- 提出药理和非药理策略来缓解CC,重点是老年人.
主要方法:
- 对癌症缓解症的分子机制和治疗干预措施的文献综述.
- 对益生菌和低剂量 olanzapine 的新兴证据进行分析.
主要成果:
- 药物治疗CC可能会导致胃肠道和心血管并发症.
- 益生菌显示出改善营养吸收和减少炎症的潜力.
- 在老年患者中,低剂量 olanzapine 可能会增强食欲和体重管理.
结论:
- 未来的CC研究应该优先考虑为老年患者开发更安全的食欲刺激药物.
- 研究营养因素以增强或预防食欲抑制对于管理弱势群体的食欲抑制至关重要.
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