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Updated: Jul 5, 2025

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
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ZFP281控制着转录和表观遗传变化,通过DNMT3和TET1促进小鼠的多能状态过渡

Xin Huang1, Sophie Balmer2, Cong Lyu3

  • 1Department of Medicine, Columbia Center for Human Development and Stem Cell Therapies, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

Developmental cell
|January 18, 2024
PubMed
概括

转录因子ZFP281直接激活DNA甲基转移酶 (DNMT3A/3B),并与TET1协调调节多能干细胞转换期间的DNA甲基化动态,保持原始多能性.

关键词:
通过DNA甲基化.在 DNMT3 中使用 DNMT3.这是一个R环.在TET1上.在 ZFP281 中,这是一个具有形成性的形式.这是天真的,天真的.多能性的多能性.预备好的初始化.

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