在老年人中,安非他胺/德克斯特罗安非他胺与甲基酸的心血管安全性
Rachel Paulmann1, Randi Stouffer1, Monica Mathys1
1Department of Pharmacy, Veterans Affairs North Texas Health Care System, Dallas, TX, USA.
这项研究发现,服用安非他林/德克斯托安非他林的老年退伍军人和服用甲基酸盐的老年退伍军人在主要心血管事件中没有显著差异. 这两种兴奋剂药物在这个人群中表现出类似的心血管安全概况.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 流行病学数据显示,老年人中兴奋剂使用量有所增加,老年人群容易受到心血管副作用的影响.
- 现有的研究表明,老年人使用兴奋剂时心血管事件增加,但对头对头的安全数据很少.
研究的目的:
- 在老年成人患者中,比较安非他胺/德克斯托安非他胺与甲基酸的心血管安全性.
- 确定严重心血管事件发生率的差异,包括心肌梗塞,中风/暂时性缺血性发作和心律失常.
主要方法:
- 50岁及以上的退伍军人2015年至2021年间处方兴奋剂的回顾性图表审查.
- 主要结局:复合性心血管事件. 二次结局:个体心血管事件 (MI,中风/TIA,心律失常).
- 使用卡普兰-梅尔曲线和危险比率进行时间到事件分析.
主要成果:
- 436名退伍军人被纳入分析 (241名安非他林/德克斯特罗安非他林,195名甲基酸).
- 在复合心血管事件中没有观察到显著差异 (5%对4.1%,P = .6635).
- 时间到事件分析也显示,两组之间没有显著差异 (P = .4966).
结论:
- 胺/胺和甲基胺在老年退伍军人中表现出相似的心血管安全性.
- 这项研究表明,在这个人群中比较这两种兴奋剂药物时,心血管重大事件的风险没有增加.
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