与右心功能相比,左心功能在败血症和败血症冲击中的预后影响
Jan Forner1, Kathrin Weidner, Jonas Rusnak
1From the Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
概括
损坏的左心室射出分数 (LVEF) 预测了没有冲击的败血症患者的死亡率,但不是发生败血症冲击的患者. 右心室功能 (TAPSE) 没有影响败血症预后.
科学领域:
- 心脏病学 心脏病学
- 关键护理医学 关键护理医学
- 败血症研究 败血症研究
背景情况:
- 败血症和败血性休克是具有高死亡率的严重疾病.
- 左心室喷射率 (LVEF) 和三环状平面缩外流 (TAPSE) 是心脏功能的关键指标.
- 这些心脏参数在败血症的预后值需要进一步阐明.
研究的目的:
- 调查LVEF和TAPSE在败血症和败血性休克患者的预后意义.
- 为了确定通过LVEF和TAPSE评估的心脏功能受损是否与30天全因死亡率相关.
主要方法:
- 分析了292名连续性败血症和败血性休克患者的队列.
- 在ICU入院后24小时内测量LVEF和TAPSE.
- 患者根据LVEF (<45%对≥45%) 和TAPSE (<17毫米对≥17毫米) 进行了分层.
主要成果:
- 降低的LVEF (<45%) 与整体队列中的30天死亡率增加有关,特别是在败血症患者中 (HR=1.919,p=0.013).
- 然而,降低的LVEF与败血症休克患者的死亡率增加无关 (HR=0.956,p=0.853).
- 损坏的TAPSE (<17毫米) 在败血症或败血性休克中与30天死亡率没有显著的关联.
结论:
- 衰弱的LVEF是没有败血症休克的败血症患者死亡率的重要预测因素.
- 在感染性休克患者中,LVEF似乎不是死亡率的预后标志物.
- 通过TAPSE评估的右心室缩功能不能预测败血症或败血性休克的结果.
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