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Updated: Jul 5, 2025

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描述了MDM2和14-3-3σ之间的蛋白质-蛋白质相互作用;对于小分子稳定概念的证明

Jake A Ward1, Beatriz Romartinez-Alonso2, Danielle F Kay3

  • 1Leicester Institute for Structural and Chemical Biology, University of Leicester, Leicester, UK; Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.

The Journal of biological chemistry
|January 18, 2024
PubMed
概括

稳定14-3-3σ/MDM2与小分子的相互作用提供了癌症治疗策略. 在S166/S186中对MDM2的脱酸化是这种相互作用的关键,这种相互作用可以通过菌素A增强.

关键词:
14-3-3 蛋白质的使用情况MDM2DM2 在线播放分子粘合剂分子粘合剂在 p53 里,p53 是一个 p53 的类型.蛋白质 蛋白质 相互作用 相互作用

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