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Updated: Jul 5, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

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Cdc6的N端区域特别识别人类DNA的G-四重复

Yanyan Geng1, Changdong Liu2, Naining Xu2

  • 1Clinical Research Institute of the First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China; Institute for Advanced Study and State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

International journal of biological macromolecules
|January 18, 2024
PubMed
概括

人类Cdc6蛋白通过其N端内在失序区域 (IDR) 结合G-四重复DNA结构. 这种特定的相互作用对于调节DNA复制启动至关重要,为基因组稳定提供了新的见解.

关键词:
在G-quadruplex中使用.本质上是无序的区域.蛋白质-DNA相互作用

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