在胰腺癌患者中改变了全血血生成和高反应性血小板
Ruth Anne Laura Willems1, Joke Konings2, Dana Huskens2
1Department of Functional Coagulation, Synapse Research Institute, Maastricht, The Netherlands; Thrombosis Expert Center Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Internal Medicine, Division of Vascular Medicine, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Internal Medicine, Division of Medical Oncology, Maastricht University Medical Center, Maastricht, The Netherlands; Cardiovascular Research Institute Maastricht (CARIM), School for Cardiovascular Diseases, Maastricht, The Netherlands.
胰腺癌患者表现出血液凝固的改变,血小板在血栓形成风险中起着关键作用. 测量全血血静止可以改善对血栓栓塞事件的风险评估.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 血栓形成的研究研究
背景情况:
- 胰腺管道腺癌 (PDAC) 显著增加了血栓栓塞性疾病的风险.
- 在PDAC患者中,血液细胞数量的变化与静脉血栓栓塞 (VTE) 有关.
- 血凝性血细胞可能导致PDAC中血栓形成的风险增加.
研究的目的:
- 为了比较PDAC患者和健康对照人群之间的血细胞依赖凝血.
- 调查PDAC中的凝血参数和血栓栓塞事件之间的关联.
主要方法:
- 血生成 (TG) 测量在全血 (WB) 和血.
- 血小板颗粒释放能力 (PGRC) 评估在WB.
- 在PDAC患者的6个月随访期间探索血栓栓塞事件的发生情况.
主要成果:
- PDAC患者在WB中表现出内源性血栓潜在的增加,但在血中没有,这表明血液细胞介导的血凝剂作用.
- PDAC患者的血小板反应过强,释放颗粒的时间较短.
- 较短的WB TG延迟时间和增加的PGRC与血栓栓塞事件相关;22%的患者患有静脉动脉瘤,6%患有动脉血栓症.
结论:
- 与对照组相比,PDAC患者表现出改变和延迟的WB TG凝血概况.
- 全血TG滞后时间和血小板颗粒释放能力与血栓栓塞事件发生率有关.
- 血小板对于血栓形成至关重要,WB血静测量可以提高PDAC中的血栓风险预测.
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