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Updated: Jul 5, 2025

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TRIB3-TRIM8复合体通过调节HNF4α稳定性来驱动NAFLD的进展

Meng-Chao Xiao1, Nan Jiang1, Li-Lin Chen2

  • 1Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.

Journal of hepatology
|January 18, 2024
PubMed
概括

在非酒精性脂肪性肝病 (NAFLD) 中,细胞内膜网膜应激通过TRIB3-TRIM8 E3结合酶复合体降解肝核因子4α (HNF4α). 破坏这种相互作用会稳定HNF4α,改善NAFLD的进展.

关键词:
肝细胞核因子4α非酒精性脂肪性肝病是非酒精性脂肪性肝病.特里布尔斯的同类3 3三方图案包含 8 个乌比奎丁是一种存在的药物.

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