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AB与ABO特异性等离子体对O型血液受体脱敏的比较分析:一种体外研究

¹Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, Korea.

Annals of laboratory medicine

|January 18, 2024

概括

对于接受ABO不兼容移植的O型血液接受者,B新鲜冷血 (FFP) 在降低抗B抗体标位方面比AB FFP更有效. 这一发现指导了对输血的ABO兼容血的选择.

科学领域:

免疫学免疫学免疫学
输血医学输血医学
血清学血清学是一门学科.

背景情况:

对于血型O的接受者来说,ABO不兼容的移植需要仔细选择ABO组特异的新鲜冷血 (FFP).
血中的可溶性ABH物质 (SAS) 在中和抗A和抗B抗体中起着至关重要的作用.
了解不同FFP ABO组的中和能力对于优化输血策略至关重要.

研究的目的:

评估血中可溶性ABH物质 (SAS) 的中和能力测量 (NCM).
为指导选择适当的新鲜冷血 (FFP) 的 ABO 组,用于血交换 (PE) 在血型 O 接收者与 ABO 不兼容移植.

主要方法:

通过测量血样本中的抗A和/或抗B标位来评估中和能力.
样本包括O FFP和O EDTA血,盐水稀释和来自不同血型的聚合FFP作为稀释剂.
在一些EDTA血样本中考虑了易斯b (Le^b) 抗原阳性.

主要成果:

在O FFP中,与AB FFP相比,B FFP对IgM和总抗B抗体具有显著更高的中和能力 (P<0.001).
在O EDTA血样本中,与AB FFP相比,B FFP在降低IgM (P=0.0013) 和总抗B (P=0.025) 抗体标位方面也表现出更大的有效性.
与AB FFP相比,B FFP在降低抗B标位方面的有效性与Le^b抗原阳性不相关.

结论:

血型B的FFP在降低O血型接受者的抗B抗体标位方面比AB的FFP更有效.
这一发现支持B FFP在O受体的ABO不兼容移植中用于血交换.
这项研究为改善移植结果的ABO兼容血选择策略提供了有价值的见解.

关键词:

有ABO血型的人有ABO血型.脱敏感化脱敏感化新鲜冷的等离子体在等离子体交换的过程中,

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