循环RNA和炎症:具有诊断作用的表观遗传调节者
Soudeh Ghafouri-Fard1, Hamed Shoorei2, Toofan Sabernia3
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pathology, research and practice
|January 18, 2024
概括
循环RNAs (circRNAs) 在免疫系统调节和炎症疾病的发展中起着关键作用. 这篇评论总结了它们在诸如败血症和关节炎等疾病中的参与.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 循环RNAs (circRNAs) 通常是非编码RNA分子,但可以产生短.
- 特定的circRNA/miRNA对与免疫相关疾病的发病有关.
- 循环RNA因其在免疫功能和炎症性疾病中的调节作用而越来越受认可.
研究的目的:
- 系统地审查和总结目前关于circRNAs在炎症和相关疾病病理病理学中的作用的文献.
- 为了确定特定的circRNA及其相关的microRNAs (miRNAs) 参与免疫相关的条件.
- 提供关于circRNA参与各种炎症疾病的全面概述.
主要方法:
- 在PubMed和谷歌学者数据库的文献搜索到2022年7月使用关键词"circRNA"和"炎症".
- 包括评估circRNAs在炎症和相关疾病病理学方面的贡献的原始研究文章.
- 从选定的文章的主要文本中表格化信息.
主要成果:
- 循环RNAs参与各种免疫相关疾病的病理病理学.
- 涉及circRNA/miRNA对的例子包括circ_Ttc3/miR-148a和circ-FBXW7/miR-216a-3p.
- 该审查涵盖了circRNA在败血症,动脉样硬化,类风湿性关节炎,骨关节炎以及与免疫相关的心血管,肺,胃肠道和神经系统疾病中的作用.
结论:
- 循环RNAs是炎症性疾病的发展和进展中的重要参与者.
- 了解circRNA机制为免疫相关疾病提供了潜在的治疗点.
- 这篇摘要强调了circRNAs在多种炎症疾病中的广泛影响.
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