针对自身感知和视觉障碍的快速在线纠正,在初级运动皮层中招募了类似的电路
Kevin P Cross1, Douglas J Cook2,3, Stephen H Scott3,4,5
1Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599 kevin_cross@med.unc.edu.
eNeuro
|January 18, 2024
概括
运动皮层通过重叠的神经回路快速纠正错误. 不同的感官反来源,如视觉目标变化或机械肢体干扰,激活类似的M1神经元群体,以快速进行运动调整.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 系统神经科学 系统神经科学
背景情况:
- 快速的运动纠正对于目标定向的运动至关重要.
- 初级运动皮质 (M1) 对于处理这些纠正的感觉反至关重要.
- 了解M1电路如何整合各种传感输入以进行快速调整仍然不清楚.
研究的目的:
- 研究主要运动皮质 (M1) 如何利用不同的感觉反源来快速进行运动纠正.
- 为了确定M1电路是否被视觉和自感扰动类似地招募.
主要方法:
- 两只雄性 rhesus 子 (Macaca mulatta) 接受了目标指导的达到任务的训练.
- 通过目标跳跃,光标跳跃或机械肢体负载 (自身感知反) 引入感觉错误.
- 在M1中记录了神经活动,并分析了对扰乱的群体级反应.
主要成果:
- 在记录的M1神经元中,大约有73%对至少一种感官扰动做出了反应.
- 响应模式显示了视觉干扰 (目标与光标跳跃) 之间的高相关性,以及机械负载和视觉干扰之间的中等相关性.
- 对神经子空间的分析揭示了不同感官反类型引起的活动模式的显著重叠,特别是在视觉扰乱之间.
结论:
- 主要运动皮层 (M1) 对感官扰动表现出广泛的反应.
- 不同的感觉反来源,包括视觉和自感受,汇聚到M1.1内的重叠的神经回路中.
- 这些发现表明,一个统一的M1电路机制用于处理各种感觉错误,以实现快速的运动纠正.
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