怀孕期间HLA和血管激素II型1受体抗体的动力学
Carla Burballa1, Laura Llinàs-Mallol1, Susana Vázquez1
1Department of Nephrology, Hospital del Mar, Barcelona, Spain; Nephropathies Research Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Human immunology
|January 18, 2024
概括
怀孕显著增加了人类白细胞抗原 (HLA) 抗体,特别是在第一次生育的母亲中,但不影响血管激素II类型1受体 (AT1R) 抗体. 先进的测试显示,在怀孕期间,HLA敏感性更高.
科学领域:
- 免疫学 免疫学 免疫学
- 生殖医学 生殖医学
- 移植科学 移植科学
背景情况:
- 诸如抗人类白细胞抗原 (HLA) 抗体和自身抗体,如血管新生素II型1受体 (AT1R) 抗体之类的阿洛抗体可以使移植复杂化.
- 怀孕是HLA抗体的已知触发因素,之前的研究通常使用较旧的方法,并专注于产后评估.
- 已经研究了AT1R抗体,主要与孕前有关.
研究的目的:
- 为了研究怀孕作为HLA和AT1R抗体的来源.
- 为了分析这些抗体在整个妊娠期间的动态.
- 为了确定影响怀孕期间抗体发育的潜在因素.
主要方法:
- 从138名孕妇收集了血清样本,分三个月的时间.
- 人类白细胞抗原 (HLA) 抗体的存在使用基于Luminex珠子的查来确定.
- ангиотензин II 1 型受体 (AT1R) 抗体水平通过酶相关免疫吸收试验 (ELISA) 测量.
主要成果:
- HLA抗体的患病率从头三个月的29.7%增加到第三个月的38.2%.
- 在整个怀孕期间,AT1R抗体保持稳定,约为30%.
- 原发性妇女的HLA抗体显著增加 (17.6%至34.1%),主要是II类,而多发性妇女的总体患病率更高 (43.2%).
- 在原发性和多发性妇女之间没有观察到AT1R抗体的显著差异.
结论:
- 怀孕是HLA抗体敏感化的重要来源,在原发性妇女中观察到显著增加,特别是对II类抗体.
- 怀孕似乎不是AT1R抗体的重要来源.
- 像Luminex这样的现代固相测试表明,与以前的评估相比,怀孕期间HLA敏感性的患病率更高.
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