早期精神病的社会动机下降与低维生素D的多基因责任有关
Alex Hatzimanolis1,2, Sarah Tosato3, Mirella Ruggeri3
1Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, Eginition University Hospital, Athens, Greece. alhatzi@med.uoa.gr.
缺乏维生素D的多基因风险与负面症状有关,例如第一发精神病 (FEP) 中的动机减少. 促进户外活动和社会参与的干预措施可以帮助FEP患者控制这些症状.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 遗传学 遗传学 是一个
- 营养科学 营养科学
背景情况:
- 维生素D不足在精神分裂症和第一发精神病 (FEP) 中很常见.
- 原因尚不清楚:生物学倾向与生活方式变化.
- 低维生素D与神经发育不良和负面精神病症状有关.
研究的目的:
- 调查维生素D多基因风险评分 (PRS-vitD) 在FEP症状表现中的作用.
- 为了确定PRS-vitD是否会影响负面症状和神经发育标志物.
主要方法:
- 利用了来自雅典FEP (n=205) 和PICOS (n=123) 队列的数据.
- 评估心理病理的严重程度,使用阳性和阴性综合征尺度.
- 作为神经发育的代理人,检查了病前智力和调整.
主要成果:
- 在雅典FEP的基线和随访中,在PRS-vitD和负面症状严重程度,特别是缺乏社会动机之间发现了反向关联.
- 这种关联在随访时在PICOS队列中得到了独立验证.
- 在PRS-vitD和前病情情报或调整措施之间没有发现显著的关系.
结论:
- 对低维生素D的多基因脆弱性可能会损害FEP中的动机和社交互动.
- 研究结果表明,鼓励户外活动和社会参与的干预措施可以减轻FEP的负面症状.
- 低PRS-vitD似乎不会影响与精神病相关的发育轨迹.
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