炎症性ADHD生物型与慢性压力有关:对炎症性蛋白质组的数据驱动分析
Isabel Schnorr1, Anne Siegl1, Sonja Luckhardt2
1Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.
Translational psychiatry
|January 18, 2024
概括
患有注意力缺陷多动症 (ADHD) 的成年人可能有两个不同的炎症特征. 在ADHD中,较高的炎症与增加的慢性压力和独特的临床特征有关.
科学领域:
- 神经炎症是一种神经炎症.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 注意缺陷多动症 (ADHD) 和低度炎症之间的联系在儿童中已经确立,但在成人中没有充分研究.
- 在ADHD的炎症是可变的,并可能受到药物,营养,吸烟和压力的影响,与不清楚的症状关联.
- 了解成人ADHD炎症概况对于有针对性的干预至关重要.
研究的目的:
- 调查ADHD成年参与者队列中的炎症蛋白质概况.
- 在成年ADHD人群中识别不同的炎症生物型.
- 探索炎症概况,临床特征和生活方式因素之间的关系.
主要方法:
- 使用OLINK技术在126名成人多动症参与者中评估了96种炎症蛋白质,同时服用稳定的药物.
- 采用无监督的等级聚类来识别不同的炎症生物型.
- 分析了生物型,临床数据,药物状况和压力等生活方式因素之间的关联.
主要成果:
- 确定了两个不同的生物型:一个具有较高的炎症潜力 (HIP) 组和一个具有较低的炎症蛋白潜力 (LIP) 组.
- HIP组与NF-κB通路,化学激素信号传递,IL-17信号传递和代谢变化具有更强的关联.
- HIP组的慢性压力,CGI-S得分和自杀风险显著增加;精神药物联合治疗影响了蛋白质水平.
结论:
- 患有多动症的成年人至少有两种不同的炎症生物型.
- 在ADHD中增加的炎症蛋白与更高的感知慢性压力线性相关.
- 未来对成年ADHD炎症的研究必须考虑慢性压力水平.
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