研究后期生活中认知变化的遗传决定因素
Liam Mahedy1,2, Emma L Anderson1,2, Kate Tilling1,2,3
1MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.
Translational psychiatry
|January 18, 2024
概括
这项研究确定了与老年人认知变化相关的新型遗传变异,特别是影响注意力. 教育多基因风险评分也影响了晚年认知,突出了认知衰老的遗传因素.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 老年学是一门学科.
背景情况:
- 认知能力下降是人口老龄化的一个重大问题.
- 了解影响认知变化的遗传因素对于开发干预措施至关重要.
- 之前的遗传研究主要集中在横截面认知上,使认知变化不太了解.
研究的目的:
- 在一个认知正常的老年人队伍中调查与认知变化的遗传关联.
- 为了确定新的遗传变异,并探索多基因风险得分在认知轨迹中的作用.
主要方法:
- 用通用估计方程 (GEE) 建模对TOMMORROW试验数据进行认知变化轨迹的全基因组关联研究 (GWAS).
- 测试多基因风险分数 (PRS) 之间的关联,以发现潜在的风险因素和认知措施.
- 对老年人队列中重复认知测量的分析.
主要成果:
- 两种基因变异rs534221751 (涉及NCAM2) 和rs34743896 (涉及CRIPT/ATP6V1E2),与注意力变化有显著的关联.
- 教育PRS与基线认知相关,特别是在语言领域,即使在65岁以上的个体中也是如此.
- 证明了在GWAS中使用GEE建模用于认知变化的可行性.
结论:
- 发现了认知变化的新型遗传关联,与横截面研究中发现的不同.
- 这项研究突出了教育PRS对生命后期认知的重大影响.
- 这些发现支持使用试验数据和轨迹建模来发现对认知变化的遗传影响的潜力.
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