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一个模块化化学酶级联策略,用于结构定制组装的化物类似物

Xuefeng Jin1,2, Hanchao Cheng3,4, Xiaohui Chen1

  • 1State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Communications chemistry
|January 18, 2024
PubMed
概括

一种新的化学酶学方法使得大规模合成甘地化物类似物能够用于药物开发. 这一策略促进了化物GM1的产生,并确定了促进神经细胞生长的修改.

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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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