测试试卷:芬太尼试卷的实验室性能
John C Halifax1, Lilly Lim2, Daniel Ciccarone3
1Department of Laboratory Medicine, ZSFG Clinical Laboratory, UCSF, 1001 Potrero Ave. Bldg. 5 2M16, San Francisco, CA, 94110, USA. john.halifax@ucsf.edu.
Harm reduction journal
|January 18, 2024
概括
芬太尼试验条 (FTS) 可以检测芬太尼和类似物,但性能因制造批量而异. 这种变化会影响准确性,需要持续评估以有效预防过量.
科学领域:
- 法医化学 法医化学
- 公共卫生 公共卫生
- 分析化学 分析化学
背景情况:
- 美国面临着由合成阿片类药物推动的不断升级的过量危机.
- 芬太尼试验条 (FTS) 是预防过量服用的关键工具.
- 评估FTS在不同制造批量中的性能一致性至关重要.
研究的目的:
- 为了评估多个芬太尼试验条 (FTS) 制造批量的有效性.
- 为了确定FTS与芬太尼及其类型的敏感性和交叉反应性.
- 识别可能导致假阳性的潜在干扰.
主要方法:
- 实验室测试连续稀释的药物标准,使用BTNX快速响应芬太尼试验条的五个制造批量 (20 ng/mL截止值).
- 对芬太尼和芬太尼类似物FTS敏感度的批量对批量变化的评估.
- 评估与常见 adulterants 和潜在干扰的交叉反应.
主要成果:
- 所有测试的FTS批量都显示了与芬太尼和11种芬太尼类似物的交叉反应性.
- 观察到的假阳性是用二胺,利多卡因,MDMA和甲基胺.
- 在FTS对芬太尼,类似物和干扰物的敏感性中,检测到大量与大量之间的显著变化.
结论:
- 芬太尼试验条对于预防过量服用有价值,但表现有变化.
- 批量对批量的不一致性使得制定明确的使用说明变得复杂.
- 需要定期的绩效评估和先进的药物检查技术来提高准确性和减少危害.
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