与Candida auris相关的住院病例和疫情,中国,2018-2023年
Jian Bing1,2, Han Du2, Penghao Guo3
1Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Emerging microbes & infections
|January 18, 2024
概括
一种危险的真菌病原体 - - 黄菌 (Candida auris) 已经在中国各地蔓延,导致住院和爆发. 大多数菌株对常见的抗真菌药物表现出耐药性,这对公共卫生构成了重大挑战.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 新兴的真菌病原体Candida auris构成了全球公共卫生威胁.
- 在2018年至2023年期间,Candida auris已经在中国10个省份被检测到.
- 这项研究详细介绍了中国Candida auris的流行病学.
研究的目的:
- 为了调查中国Candida auris的流行病学.
- 分析中国Candida auris的遗传多样性和抗真菌耐药性模式.
主要方法:
- 对Candida auris分离物的分子流行病学分析.
- 在医疗保健机构追踪住院和疫情.
- 抗真菌易感性测试. 抗真菌易感性测试.
主要成果:
- 在中国 (2018-2023) 报告了312例住院治疗和4起与Candida auris相关的疫情.
- 鉴定出了三种不同的Candida auris遗传基因.
- 观察到对可纳的高耐药率 (98.7%),对安福特瑞辛B (4.2%) 和卡斯波金 (2.2%) 的耐药率较低.
结论:
- 黄虫在中国已经存在,有多次引入和本地传播.
- 该病原体表现出显著的抗真菌耐药性,特别是对可纳.
- 有效的监测和治疗策略对于在中国管理Candida auris至关重要.
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