在肥胖的孕妇中,母亲对怀孕的心血管适应
Deesha Patel1, Martina Avesani2, Mark R Johnson1
1Academic Department of Obstetrics and Gynaecology, Chelsea & Westminster Hospital, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.
肥胖的孕妇表现出高动态的血液循环,心脏结构的改变,以及扩张功能受损. 肥胖的这些心血管变化可能会增加怀孕并发症的风险.
科学领域:
- 心血管生理学心血管生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 肥胖医学 肥胖医学
背景情况:
- 肥胖是妊娠期间高血压疾病的重要危险因素.
- 肥胖对母亲心脏功能的具体影响仍未得到充分研究.
- 了解这些影响对于管理高风险妊娠至关重要.
研究的目的:
- 调查肥胖对孕期母亲心血管系统适应的影响.
- 为了比较肥胖和不肥胖的孕妇的心脏几何和功能.
主要方法:
- 前性,观察性,纵向性研究设计.
- 孕妇肥胖 (BMI ≥30 kg/m2) 和正常BMI (20-24.9 kg/m2) 的比较.
- 通过使用多层线性混合效应模型在多个妊娠点通过心声学评估血压,心脏几何和功能.
主要成果:
- 肥胖女性表现出更高的血压,心率和心脏输出量,以及较低的周围血管阻力.
- 在肥胖女性中观察到心脏几何学的显著变化,包括左心室尺寸和质量增加.
- 肥胖组中明显出现了扩张功能损失和纵向缩功能减少.
结论:
- 肥胖与孕妇的高动力循环,心脏几何变化和怀孕期间的腹功能障碍有关.
- 在肥胖的孕妇中,这些心血管变化可能会导致妊娠并发症的风险增加.
- 需要进一步的研究来阐明对母亲和胎儿的长期心血管影响.
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